Skin · Sinsa, Gangnam · Seoul

PDRN Anti-Ageing Therapy in Seoul

A gentle regenerative injection for dull, stressed or sensitive skin and for faster settling after lasers. Dr. Lee Yoo-jung uses PDRN where the skin needs calm and recovery more than structure.

Free consultation on WhatsApp → See before & after
Calm, even skin tone after PDRN anti-ageing therapy at UE Plastic Surgery, Gangnam
15–30 min treatment time
Under 1 day typical visible bumps
3–5 sessions usual course, 2–4 weeks apart
14 yrs Dr. Lee as a board-certified surgeon

The short answer

PDRN (polydeoxyribonucleotide) therapy injects short, purified DNA fragments, usually derived from salmon, into the skin. PDRN is thought to support tissue repair and reduce inflammation, so it is used for dull or sensitive skin, uneven tone and recovery after laser treatment. It adds no volume, works gradually over a course of sessions, and the small injection bumps normally settle within a day.

Dr. Lee Yoo-jung, board-certified plastic surgeon
Medically reviewed by Dr. Lee Yoo-jung , board-certified plastic surgeon · M.D., Ajou University · former director, Banobagi
Last reviewed
i.

What is PDRN therapy?

PDRN stands for polydeoxyribonucleotide, a mixture of short DNA fragments. It was first used in wound-healing medicine; in aesthetics it is injected into the dermis to help the skin repair itself and settle redness. The result is skin that looks calmer, more even and better rested rather than plumper.

PDRN is a lighter cousin of the polynucleotide in Rejuran, which uses longer chains and has a more structural effect. Where texture is the main issue, Rejuran or Juvelook may suit better; where tone and sensitivity are, PDRN is often the gentler start.

ii.

Who is PDRN therapy for?

  • Dull, tired-looking skin after stress, illness or long-haul travel.
  • Sensitive or easily reddened skin that reacts to stronger treatments.
  • Uneven tone and early fine lines.
  • Recovery after lasers or microneedling to settle redness faster.
  • First-time patients who want a low-downtime introduction to injectables.

As with Rejuran, PDRN is derived from fish, so it is not for anyone with a fish allergy.

iii.

PDRN vs Rejuran vs PRP

PDRN Rejuran (PN) PRP
Source Purified salmon DNA Purified salmon DNA Your own blood
Fragment size Short Long chains —
Best for Tone, calm, recovery Texture, elasticity General skin quality
Feel during injection Mild Stronger sting Mild
Typical course 3–5 sessions 3 sessions 2–3 sessions

If you prefer an option made from your own blood, see PRP facial rejuvenation.

iv.

How a PDRN session is done

01 Assessment Dr. Lee checks redness, sensitivity and texture and decides whether PDRN alone or a combination is sensible.
02 Numbing Numbing cream for 20–30 minutes.
03 Injection Fine micro-injections into the dermis, or delivery after a laser session to aid recovery.
04 Aftercare Soothing mask and sun-protection advice before you leave.
v.

Before & after

Before and after facial rejuvenation with a fresher lower face Before After
Representative lower-face case at UE Plastic Surgery, shared with consent. Your treatment plan may differ. Individual results vary.

More cases are in our before & after gallery.

vi.

What happens after treatment?

First hours Tiny bumps and pinkness at injection points.
Next day Most marks gone; make-up and normal routine.
Week 2–4 Next session; tone looks more even.
After the course Maintenance every few months if you like the result.

“For reactive skin I start gently. Calm skin responds far better to everything that comes after.”

Dr. Lee Yoo-jung · Chief Director
vii.

Side effects and risks

Side effects are generally mild: brief stinging, small bumps and occasional pinpoint bruising. Allergy and infection are uncommon. The effect is subtle and cumulative; PDRN will not lift sagging skin, and we will tell you so if that is your main concern.

viii.

Frequently asked questions

Is PDRN the same as salmon DNA injections?

Yes, "salmon DNA" is the popular name. The material is highly purified for medical use.

How many PDRN sessions do I need?

Three to five sessions two to four weeks apart is a typical course.

Can I wear make-up afterwards?

Usually from the next day, once the injection points have closed.

Is PDRN better than Rejuran?

Neither is better overall. PDRN suits calm and tone; Rejuran suits texture and elasticity.

Can I combine PDRN with lasers?

Yes. It is often given after laser or energy treatments to help the skin settle.

Who performs the injections?

Dr. Lee Yoo-jung plans and performs the treatment herself.

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Related procedures.

i. Rejuran Healer Polynucleotides for texture. ii. PRP Facial Rejuvenation Your own platelets. iii. Skin Booster Injections Hydration and glow. iv. LDM Treatment Soothing ultrasound care. v. Laser Lifting Tightening to pair with PDRN. vi. Rejuran Cost Regenerative injection prices.

Free consultation · English-speaking

Let’s talk.

Send a photo of your skin without make-up on WhatsApp and Dr. Lee will tell you whether PDRN is the right place to start.

WhatsApp us → +82 2 516 6160
Address
16F, 616 Gangnam-daero, Gangnam-gu, Seoul · Sinsa Station Exit 6
Hours
Mon–Fri 10:00–19:00 · Sat 09:30–15:30
Surgeon
Dr. Lee Yoo-jung, board-certified plastic surgeon

This page is for general information and does not replace an in-person medical consultation. Results and recovery differ between individuals.